Personal Statement

I have experience, motivation and expertise to serve and treat your chronic pain. I started my career as an interventional radiologist and from that experience through it, I had a clinical question "Why can a blood vessel with disturbed structure be formed in cancer or inflammation?" And to solve it, I will focus on abnormal capillary when I was engaged in basic research of vascular science that I did during my graduated student researcher. From this work we found genes involved in the pathogenesis of abnormal capillary and I reported the results of the study to Nature Medicine in 2012 as a first author. Based on these experiences, from the viewpoint that reduction of abnormal diseased blood vessels leads to improvement of chronic inflammatory diseases and chronic pain, I have developed a treatment using embolization technique applying to chronic musculoskeletal disorders, such as knee osteoarthritis and frozen shoulder and reported its safety and usefulness in the world for the first time by conducting clinical researches. At present, this procedure is beginning to be confirmed for safety and usefulness in third parties in other countries.

1. Okuno, Y., Nakamura-shizu, A., Otsu, K., Suda, T. & Kubota, Y. Pathological neoangiogenesisdepends on oxidative stress regulation by ATM. Nature Med 2012

2. Okuno Y, Oguro S, Iwamoto W, Miyamoto T, Ikegami H, Matsumura N.　Short-term results of transcatheter arterial embolization for abnormal neovessels in patients with adhesive capsulitis: a pilot study. J Shoulder Elbow Surg. 2014 Mar 4　

3. Okuno Y, Korchi AM, Shinjo T, Kato S. Transcatheter arterial embolization as a treatment for medial knee pain in patients with mild to moderate osteoarthritis. Cardiovasc Intervent Radiol. 2014 Jul 4.

Positions and Honors

• 2006-2009
  Fellow, Department of Radiology, Clinica ET, Yokohama, Japan
• 2009-2012
  Researcher, Center for Integrated Medical Research, Keio University, Tokyo, Japan
• 2012-2015
  Clinical Researcher, Department of interventional radiology, Edogawa Hospital, Tokyo, Japan
• 2015-
  Director, Musculoskeletal Intervention Center, Edogawa Hospital, Tokyo, Japan
• 2016-
  Assistant professor, Department of Orthopedic surgery, Toho University, Tokyo, Japan
• 2017-
  Chief Director of Okuno Clinic.

• 2012
  Excellence in Basic Scientific Research, Keio University, Tokyo, Japan
• 2013
  Poster Award “Runner Up”, British Society of Interventional Radiology
• 2014
  Poster Award “Cum Laude”, Cardiovascular Interventional Radiological Society of Europe
• 2014
  Award of excellent Poster, Global Embolization Symposium and Technologies Asia

PEER REVIEWED PUBLICATIONS

1. Okuno, Y., Nakamura-Ishizu, A., Kishi, K., Suda, T. & Kubota, Y. Bone marrow-derived cells serve as proangiogenic macrophages but not endothelial cells in wound healing. Blood 2011
2. Okuno, Y., Nakamura-shizu, A., Otsu, K., Suda, T. & Kubota, Y. Pathological neoangiogenesisdepends on oxidative stress regulation by ATM. Nature Med 2012
3. Okuno Y, Matsumura N, Oguro S. Transcatheter arterial embolization using imipenem/cilastatin sodium for tendinopathy and enthesopathy refractory to non-surgical management. Journal Vascular Intervent Radiol 24 (2013) pp. 787-792
4. Okuno Y, Oguro S, Iwamoto W, Miyamoto T, Ikegami H, Matsumura N.　Short-term results of transcatheter arterial embolization for abnormal neovessels in patients with adhesive capsulitis: a pilot study. J Shoulder Elbow Surg. 2014 Mar 4　
5. Okuno Y, Korchi AM, Shinjo T, Kato S. Transcatheter arterial embolization as a treatment for medial knee pain in patients with mild to moderate osteoarthritis. Cardiovasc Intervent Radiol. 2014 Jul 4.
6. Okuno Y, Iwamoto W, Matsumura N, Oguro S, Yasumoto T, Kaneko T, Ikegami H. Clinical Outcomes of Transcatheter Arterial Embolization for Adhesive Capsulitis Resistant to Conservative Treatment. Journal Vascular Intervent Radiol. 2017
7. Okuno Y, Korchi AM, Shinjo T, Kato S, Kaneko T. Mid-term Clinical Outcomes and MRI Changes after Transcatheter Arterial Embolization as a Treatment for Mild to Moderate Knee Osteoarthritis that is Resistant to Conservative Treatment. J Vasc Intervent Radiol. 2017
8. Iwamoto W, Okuno Y, Matsumura N, Kaneko T, Ikegami H. Transcatheter arterial embolization of abnormal vessels as a treatment for lateral epicondylitis refractory to conservative treatment: a pilot study with a 2-year follow-up. J Shoulder Elbow Surg. 2017